Reducing Your Risk of Esophageal Cancer
Esophageal cancer can be a debilitating disease. According to the Canadian Cancer Society, only 16% of Canadians with esophageal cancer will live longer than 5 years past their diagnosis, and this decreases to 5% if the cancer spreads to other parts of the body.
April is esophageal cancer awareness month – a great time to learn about risk factors for this type of cancer and ways to reduce your own risk. There are many lifestyle habits that affect the risk of developing esophageal cancer. In fact, it is estimated that 30–50% of cases are preventable. (1)
Modifiable risk factors for esophageal cancer
Tobacco and Alcohol
Tobacco and alcohol are two major risk factors. Smokers are five times more likely to develop esophageal cancer compared to non-smokers. Additionally, people who smoke pipes, cigars, or use smokeless tobacco are also at increased risk. Whereas the duration of use is more important when it comes to tobacco, the amount is more important when it comes to alcohol. Those who have 5–11 drinks per week are about twice as likely to develop squamous cell carcinoma (SCC) of the esophagus; this increases to seven times more likely for more than 30 drinks per week. As you might expect, drinking alcohol combined with smoking increases risk more than either one alone. (2)
Smoking cessation has profound effects, even in people already diagnosed with esophageal cancer. 5-year survival rates improve by about 25% in patients who quit smoking before or during treatment compared to patients who continue to smoke. (3) The American Cancer Society has a great webpage depicting the benefits of quitting smoking over time. Benefits are seen within a few minutes, and your risk of developing esophageal cancer can drop by up to 50% in just two to five years. There are also benefits to alcohol cessation; however, the effects are not as immediate or profound. A recent study from France has shown that, for people with alcohol dependence, rehabilitation was associated with lowered risks of alcohol-associated cancers, including esophageal cancer. (4)
Nutrition and Weight
There are many aspects of nutrition that can affect the risk of esophageal cancer. Obesity and drinking very hot beverages are the two most studied factors linked to increased risk. Although body mass index (BMI) is not the most accurate measure of a healthy weight, people with a BMI between 25 and 30 are almost three times more likely to develop esophageal cancer compared to those between 18 and 25. (5) Drinking very hot beverages may also increase the risk of esophageal cancer. A 2021 meta-analysis of 23 clinical trials showed an increased risk for those who drink tea at higher temperatures. (6) Currently, the international agency for research on cancer classifies drinking “very hot beverages” (i.e., those above 65°C) as “probably carcinogenic.” The reason for the uncertainty is due to the nature of the studies conducted. It is very difficult to determine a temperature cut-off given many of the studies relied on patient recall and subjectivity (e.g., “How hot do you like your coffee? Hot? Very hot?”). Although there is a higher risk at higher temperatures, no associations have been found between the amount of coffee/tea and esophageal cancer risk. (7)
Diets high in fibre, fruits, and vegetables are associated with a decreased risk of esophageal cancer, as well as several other types of cancer. These nutrients are also important for digestive and heart health, weight management, and blood sugar control. Despite their importance, many Canadians do not eat the recommended number of fruits and vegetables and are generally below the recommended daily intake of fibre. (8,9) These benefits are incremental and a small change can make a big difference. For example, research shows increasing your fibre intake by 10g per day reduces esophageal cancer risk by 31%. (10) 10g of fibre could be ¾ of a medium avocado, ⅔ cup of cooked lentils, or ½ a cup of cooked beans.
Tips and tools
Smoking cessation
Although quitting can be challenging, there are strategies and supports to improve long-term success. Using social support, along with behavioural and pharmacological interventions, is key to smoking cessation. Research shows that unaided quitting has only a 3 – 5% success rate in the first year. (11) Here are some resources to consider:
Smokers’ Helpline (Canadian Cancer Society)
- They can provide free text support and coaching, personalized quit plans and information about nicotine replacement therapy (NRT)
- Check out their website: www.smokershelpline.ca, or call or text 1-866-366-3667
QuitNow (British Columbia)
- Offers text support and coaching for BC residents; however, their forums and downloadable resources can be used by anyone online
- Check out their website www.quitnow.ca
Beyond these resources, use a smoking diary to help track your progress, such as this one created by the Centre for Addiction and Mental Health (CAMH), can be extremely beneficial. Finally, working with a licensed healthcare provider, such as a family doctor, nurse practitioner, or naturopathic doctor, is important. They can suggest/prescribe medications, such as nicotine replacement therapy, and provide resources to encourage behaviour changes.
Acupuncture
There is some evidence that acupuncture can aid in smoking cessation. A 2024 review showed that acupuncture and acupressure appear to be safe and effective in achieving short-term (i.e., ≤ 6 months) smoking cessation; however, the certainty of the evidence was low and long-term follow-up has not been extensively studied. (12) Another meta-analysis from 2019 showed acupuncture in combination with counselling or a smoking cessation program was more effective than acupuncture alone. (13) Based on the most recent evidence, acupuncture can be considered as a complementary approach for people trying to quit smoking, especially when combined with standard treatments, but it does not have strong evidence to be used as a stand-alone, first-line therapy.
Reducing alcohol intake
There is a continuum of risk associated with alcohol use. Generally, consuming two drinks per week or less is not associated with increased risk to yourself or others. If you are trying to reduce your alcohol intake, consider how much you currently consume on a weekly or monthly basis and how much you can commit to reducing. Some tips from Canada’s guidance on alcohol and health include:
- Setting drinking limits. Use the World Health Organization’s guideline (14) for alcohol risk and try and reduce by one risk level at a time.
- Alternate between alcoholic and non-alcoholic drinks.
- Measure your drinks to track your intake accurately
For those with alcohol use disorder, there are other interventions, such as medications, which can control cravings. Be sure to speak to a healthcare provider for more information and resources.
What are some non-alcoholic drinks you can enjoy?
- Unsweetened cranberry juice or other
- Water with berries, sliced cucumber, or a squeeze of lemon
- Canadian non-alcoholic beer companies:
- Partake Brewing (Toronto, ON)
- Libra Beverage Co. (Charlottetown, PE)
- Nevertheless Brewing (Victoria, BC) - Canadian dealcoholized wine producers:
- Zero lush (Canada-wide)
- Teetotaler Wines (Toronto, ON)
- ONES (Okanagan Valley, BC) - Carbonated water – flavoured options
- Clearly Canadian
- Balloon
- Flow
Optimizing nutrition, and nutrition for weight loss
Changing your diet can feel overwhelming, but there are many ways to take more manageable, “bite-sized” steps. While some of these strategies can also lead to weight loss, it is important to remember that increasing your fibre, fruit and vegetable intake, and having a BMI between 18 and 25 are two separate risk factors. This means, if you have a BMI between 18 and 25 but your fibre, fruit and vegetable intake is low, you may also be at an increased risk.
- Add more fruits and vegetables to your grocery list, and enjoy them as:
- Main dishes (quinoa Greek salad, vegetarian lasagna, mushroom or cauliflower tacos, vegetarian stuffed peppers)
- Sides (steamed broccoli, arugula side salad, roasted Brussel sprouts)
- Snacks (veggies and hummus, sliced apples and nut butter) - Try meatless Mondays
- Switch from white pasta and bread to whole grain varieties
- Incorporate other high-fibre foods, such as:
- Oats – oatmeal, overnight oats, or add oats to baked goods
- Nuts and seeds – trail mix as toppings on salads, yogurt or oatmeal
- Legumes (lentils, beans, peas, chickpeas, soybeans) – lentil Bolognese, lentil soup, a side of green beans, peas or edamame, or roasted chickpeas - Lastly, consider working with a dietician, naturopathic doctor, or other licensed healthcare provider who has experience with nutrition for cancer prevention and sustainable weight loss
Mark is a full-time clinical trial coordinator with the Patterson Institute for Integrative Oncology Research. He is involved in the development, implementation, day-to-day activities, and publication of all clinical research conducted at the CHI. Mark joined Dr. Dugald Seely, ND’s research team in 2018 after volunteering with his brother, Dr. Andrew Seely, at The Ottawa Hospital. Mark is also an employee of The Ottawa Hospital Research Institute, a Certified Clinical Research Professional (CCRP), and an active member of both the Canadian College of Naturopathic Medicine and Ottawa Health Sciences Network Research Ethics Boards.
Erica is a licensed naturopathic doctor at The Centre for Health Innovation, where she works with people affected by cancer, digestive concerns and mental health conditions such as anxiety, eating disorders and ADHD. Erica joined the team at The Patterson Institute for Integrative Oncology Research as a research assistant in 2022 and has been practicing naturopathic medicine for over four years. She is also a member of the research committee for the Oncology Association of Naturopathic Physicians and the Psychiatric Association of Naturopathic Physicians.
References
- Then EO, Lopez M, Saleem S, et al. Esophageal Cancer: An Updated Surveillance Epidemiology and End Results Database Analysis. World J Oncol. Apr 2020;11(2):55-64. doi:10.14740/wjon1254
- sadat Yousefi M, Sharifi-Esfahani M, Pourgholam-Amiji N, et al. Esophageal cancer in the world: incidence, mortality and risk factors. Biomedical Research and Therapy. 2018;5(7):2504-2517.
- Jassem J. Tobacco smoking after diagnosis of cancer: clinical aspects. Translational Lung Cancer Research. 2019:S50-S58.
- Hill C. Alcohol in France: room for improvement. The Lancet Public Health. 2024;9(7):e416-e417. doi:10.1016/S2468-2667(24)00124-5
- Wheeler JB, Reed CE. Epidemiology of esophageal cancer. Surg Clin North Am. Oct 2012;92(5):1077-87. doi:10.1016/j.suc.2012.07.008
- Luo H, Ge H. Hot Tea Consumption and Esophageal Cancer Risk: A Meta-Analysis of Observational Studies. Front Nutr. 2022;9:831567. doi:10.3389/fnut.2022.831567
- Islami F, Boffetta P, Ren JS, Pedoeim L, Khatib D, Kamangar F. High-temperature beverages and foods and esophageal cancer risk--a systematic review. Int J Cancer. Aug 1 2009;125(3):491-524. doi:10.1002/ijc.24445
- Polsky JY, Garriguet D. Change in vegetable and fruit consumption in Canada between 2004 and 2015. Health Rep. Jun 24 2020;31(4):3-12. doi:10.25318/82-003-x202000400001-eng
- Government of Canada. Fibre. Accessed 2025-03-13, https://www.canada.ca/en/health-canada/services/nutrients/fibre.html
- Sun L, Zhang Z, Xu J, Xu G, Liu X. Dietary fiber intake reduces risk for Barrett's esophagus and esophageal cancer. Crit Rev Food Sci Nutr. Sep 2 2017;57(13):2749-2757. doi:10.1080/10408398.2015.1067596
- Onwuzo CN, Olukorode J, Sange W, et al. A Review of Smoking Cessation Interventions: Efficacy, Strategies for Implementation, and Future Directions. Cureus. Jan 2024;16(1):e52102. doi:10.7759/cureus.52102
- Zhang Y-Y, Su Y-Z, Tian Z-Y, et al. Acupuncture and related acupoint therapies for smoking cessation: An umbrella review and updated meta-analysis. Tobacco induced diseases. 2024;22:10.18332/tid/186147.
- Wang JH, van Haselen R, Wang M, et al. Acupuncture for smoking cessation: A systematic review and meta-analysis of 24 randomized controlled trials. Tob Induc Dis. 2019;17:48. doi:10.18332/tid/109195
- Risk L, Risk VH. Incorporating Harm Reduction Into Alcohol Use Disorder Treatment and Recovery.
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