Research at the CHI
Research at the CHI is led by our CEO who serves as Executive Director for the Patterson Institute for Integrative Oncology Research. The Patterson Institute is responsible for the integrative and naturopathic oncology research conducted by the Canadian College of Naturopathic Medicine (CCNM). Our research involves the conduct of clinical trials, observational studies, and synthesis research relating to complementary and integrative medicine most relevant to cancer.
Research Summaries for Integrative Therapies
To support informed decision-making, we are committed to developing evidence-based research summaries for selected integrative cancer therapies. These summaries also called monographs, synthesize the safety and effectiveness of some of the more invasive and controversial complementary therapies used in the context of cancer.
Here you will find the research summaries we have published to date. There are patient versions (a quick summary) as well as health professional versions (a longer, fully cited and more detailed summary). We do our best to keep the monographs up to date, however please note that the monographs only encompass information known at the time of writing.
Patient Versions
Intravenous Vitamin C last updated February 2023
Mistletoe (Viscum album) last updated November 2022
Dichloroacetate (DCA) last updated June 2022
Locoregional Hyperthermia (LRHT) last updated May 2021
Coriolus Versicolor (Turkey Tail Mushroom) last updated October 2015
Acupuncture last updated February 2014
Alpha Lipoic Acid (ALA) last updated March 2014
Green Tea (Camellia sinensis) last updated February 2014
Black Cohosh for Breast Cancer last updated February 2014
Flax for Breast Cancer last updated February 2014
Red Clover for Breast Cancer last updated February 2014
Soy for Breast Cancer last updated February 2014
Vitamin D for Breast Cancer last updated February 2014
Health Professional Versions
Intravenous Vitamin C last updated February 2023
Mistletoe (Viscum album) last updated November 2022
Dichloroacetate (DCA) last updated June 2022
Locoregional Hyperthermia (LRHT) last updated May 2021
Coriolus Versicolor (Turkey Tail Mushroom) last updated October 2015
Acupuncture last updated February 2014
Alpha Lipoic Acid (ALA) last updated January 2014
Green Tea (Camellia sinensis) last updated January 2014
Black Cohosh for Breast Cancer last updated August 2013
Flax for Breast Cancer last updated August 2013
Red Clover for Breast Cancer last updated August 2013
Soy for Breast Cancer last updated August 2013
Vitamin D for Breast Cancer last updated August 2013
Active and Ongoing Research Studies
Study Status: Recruiting
Our research team has partnered with the Ottawa Hospital Research Institute to create the first randomized clinical trial in North America studying the real-world effects of integrative care guided by a naturopathic doctor (ND) in patients with lung and gastro-esophageal cancers. Patients in this study will receive either recommendations from an ND alongside their conventional treatments (integrative group) or conventional care alone (control group). Outcome measures include quality of life, qualitative experience, adverse events, blood markers, and survival. Together with other clinics across Ontario, the study team will recruit and follow 350 participants over the next 10 years.
Clinical trials identifier: NCT02845479
Study Status: Application Submitted
We have partnered with the Ottawa Hospital Research Institute have partnered to conduct a blinded, randomized clinical trial evaluating the effectiveness of intravenous vitamin C (IVC) on the quality of life of patients with incurable lung cancer. Patients in the treatment arm will receive routine chemotherapy plus high dose IVC for 6 months, with those in the control arm receiving routine chemotherapy plus a placebo infusion for the same duration. Outcomes include quality of life, chemotherapy-associated side effects, safety, progression, and survival. We plan to enroll 90 patients who will be followed over the next 8 years.
Study Status: Closed to Recruitment
Working in partnership with Bastyr University, we have initiated a North American study to explore the impact of complementary care delivered by NDs for patients with advanced breast, colorectal, ovarian, and pancreatic cancer. 12 clinics across North America have recruited patients to participate in this prospective observational study to describe quality of life, costs, qualitative experiences, and survival outcomes. Recruitment is now complete, with 400 patients enrolled, and the data is currently being analyzed.
Clinical trials identifier: NCT02494037
Study Status: Closed to Recruitment
We have partnered with the Ottawa Hospital Research Institute to conduct a blinded, placebo controlled, randomized clinical trial studying the effectiveness of dietary supplements in treating patients in the community with COVID-19. Patients in the treatment arm will receive vitamin C, vitamin D, vitamin K2, and zinc for 21 days, with those in the control arm receiving a placebo. Outcomes to be measured include overall health, health status, symptom severity and duration, and frequency of hospitalizations. Recruitment for this study was terminated prematurely due to feasibility concerns in October 2022 and the data is currently being analyzed.
Clinical trials identifier: NCT04780061
Study Status: Recruiting
Our research team is evaluating the Inspire Now program – a support program for people living with lung cancer. 50 program participants will be recruited in order to determine if the program has an effect on the quality of life, specific concerns, and general wellbeing of the participants. Researchers are utilizing quantitative and qualitative methods to track participant experiences throughout the program. This study is currently active and recruiting with each program session; all who are eligible for the program are able to participate in this research study.
Study Status: Closed to Recruitment
This study aims to explore the effectiveness of the yoga therapy program offered at the CHI for improving autonomic nervous system functioning and patient-reported outcomes among cancer survivors. Anecdotal evidence suggests yoga therapy can help lower stress, increase body awareness, and feelings of empowerment; however, the effectiveness of this intervention in promoting autonomic nervous system functioning and improving patient-reported outcomes has not been empirically evaluated. Specifically, the study seeks to determine if there are changes in self-reported and objective autonomic nervous system functioning in cancer survivors before and after a one-on-one yoga therapy session, and after a 6 week group yoga therapy program, and whether these changes are maintained for 6 weeks after completion of the yoga program. This study is a collaborative effort between the CHI and the University of Ottawa.
Research Team
Dr. Dugald Seely, ND, M.Sc.
Executive Director
Dugald Seely is a naturopathic doctor with a clinical practice focused on cancer care who has been involved in research since graduation from the Canadian College of Naturopathic Medicine (CCNM) in 2003. Dr. Seely serves as clinic director at the CHI and leads the research as Executive Director for CCNM’s Patterson Institute for Integrative Oncology Research. Dr. Seely completed his MSc in cancer research at the University of Toronto in 2007 and has been a Fellow of the American Board of Naturopathic Oncology (FABNO) since 2012. As a clinician scientist, Dr. Seely has been awarded over 11 million dollars in competitive grant and trainee funding from the Lotte and John Hecht Memorial Foundation, CIHR, CBCRA, the SickKids Foundation, the Ottawa Regional Cancer Foundation and the Gateway for Cancer Research. In addition to clinical research, Dr. Seely has conducted and supervised dozens of synthesis reviews and meta-analyses with the goal of building on the growing body of evidence that supports integrative and naturopathic oncology.
Dr. Seely is an adjunct professor with the Faculty of Medicine at the University of Ottawa, is an affiliate investigator with the Ottawa Hospital Research Institute, and is an assistant editor for the journals Current Oncology and Integrative Cancer Therapies. Dr. Seely was one of the founding directors of the Knowledge in Integrative Oncology Website (KNOW) and is Past President of the Oncology Association of Naturopathic Physicians (OncANP). Having published over 100 peer-reviewed publications and chapters, Dr. Seely has spoken frequently at national and international conferences with the goal of expanding consciousness towards a more proactive model of healthcare. In 2017 Dr. Seely was the recipient of the Dr. Rogers Prize for excellence in Complementary and Alternative Medicine and in 2022 was the winner of the International Sheikh Zayed award for excellence in naturopathy research.
Dr. Ellen Conte, ND
Research Associate
Dr. Ellen Conte is a naturopathic doctor and clinical researcher with a focus in integrative cancer care. In addition to her clinical practice at Halifax Naturopathic, Ellen is an associate researcher with the Canadian College of Naturopathic Medicine and the Patterson Institute for Integrative Oncology Research where she studies the effects of a complementary and integrative approach to cancer care. Her work has been published in peer-reviewed medical journals and presented at academic conferences. Ellen completed a degree in biochemistry from the University of Ottawa prior from obtaining her Doctor of Naturopathy from The Canadian College of Naturopathic Medicine (CCNM), she then completed a 2-year residency at the Ottawa Integrative Cancer Centre, and is board certified in naturopathic oncology through the American Board of Naturopathic Oncology (FABNO). Ellen is involved with the Oncology Association of Naturopathic Physicians as a board member and as Chair of the Research Committee, she is also on the editorial review board for the Canadian Association of Naturopathic Doctors Journal.
Mark Legacy, BSc, CCRP
Research Coordinator
Mark is a full-time researcher with the Patterson Institute for Integrative Oncology Research. He functions as trial coordinator and is involved in the development, implementation, day-to-day activities, and publication of all clinical research conducted at the CHI. Mark joined Dr. Seely’s research team in 2018 after volunteering with his brother, Dr. Andrew Seely, at The Ottawa Hospital in 2017. Mark is also an employee of The Ottawa Hospital Research Institute (OHRI), working closely and often collaboratively with the Thoracic Surgery Research Team. In 2021, he became a Certified Clinical Research Professional with the Society of Clinical Research Associates, and in 2022 he joined the Ottawa Health Sciences Network Research Ethics Board, the ethics committee which oversees clinical research at the OHRI. With most of the research at the CHI being the first of its kind, Mark and his colleagues are eager to provide new insights to the field of integrative oncology.
Dr. Mohamed El Sayed, MD (Egypt), ND, PhD
Research Assistant
In addition to being a registered naturopathic doctor, Mohamed is a foreign-trained medical doctor from Egypt, holding both M.Sc. and Ph.D. degrees in radiation oncology. He has held clinical, research, academic, and administrative positions in oncology for nearly 20 years. Mohamed is a research assistant at the Patterson Institute for Integrative Oncology Research at the Canadian College of Naturopathic Medicine (CCNM). He is also a teaching assistant for clinical courses at CCNM. He focuses on integrative medicine, as well as supportive and integrative oncology care. He follows the evidence-informed approach and is passionate about research and teaching. Mohamed has published 29 journal articles and is a reviewer for four international peer-reviewed oncology journals.
“Throughout my journey in cancer patient care, I have recognized that individuals require a diverse mix of supportive care during conventional medical therapy. The research we are conducting at the Patterson Institute will open the path for healthcare providers to integrate a variety of evidence-based supportive measures and help people living with cancer understand their needs and make well-informed decisions.”
Dr. Rebecca Vanschyndel, PhD
Qualitative Research Consultant
Dr. Rebecca Van Schyndel completed the Rehabilitation Sciences PhD program at the University of Ottawa. Rebecca is a Qualitative Research Consultant with the Centre for Health Innovation.
Dr. Erica Rizzolo, ND
Research Assistant
Dr. Erica Rizzolo, ND is a licensed naturopathic doctor and research assistant at the Patterson Institute for Integrative Oncology Research. Prior to naturopathic medical school, she completed her undergraduate degree in Kinesiology at McMaster University, where she also worked as a personal trainer. Erica is an active member of the research committee for the Oncology Association of Naturopathic Physicians (OncANP) and is passionate about integrative oncology research.
In practice, she focuses on supporting people affected by cancer from initial diagnosis through chemotherapy, surgery, and preventing recurrence. She helps patients manage side effects, energy levels and mental health throughout all stages of their cancer journey. In addition to supportive cancer care, she has a clinical focus on mental health concerns including stress management and anxiety, as well as Inflammatory Bowel Disease (IBD), and sports nutrition.
Dr. Rizzolo’s clinical approach is evidence-based and patient-centered. She enjoys working with patients to create realistic and sustainable treatment plans, through the use of nutrition, physical activity, supplements, herbal medicine and counselling.
Dr. Julie Robinson, ND
Research Assistant
Julie completed her Bachelor of Science in Nursing degree at St. Francis Xavier University. During her time in the program, she became acutely aware of the importance of complementary care alongside conventional care. This led to her enrolment in the Canadian College of Naturopathic Medicine (CCNM), where she completed her 4-year degree to become a Naturopathic Doctor.
Her clinical practice focuses primarily on supporting patients with cancer, cardiovascular disease, and menopause. She uses the best available research to guide her decision making which has fueled her passion for supporting advancements in the field of naturopathic medicine by contributing to research publications. She is a research associate at the Knowledge in Integrative Oncology Website (KNOW database), and an active member of the Oncology Association of Naturopathic Physicians (OncANP).
Research Publications
Browse by Year
Vitamin D and Multiple Myeloma: A Scoping Review
Authors: Mirhosseini, N., Psihogios, A., McLaren, M.D., Seely, D.
Journal: Current Oncology
Publication Date: March 11th, 2023
Citation: Current Oncology 30.3 (2023): 3263-3276.
Complete Remission of BCG-Refractory High-Grade Bladder CIS with Pharmacologic Ascorbate and Mistletoe
Authors: Davis, D., Seely, D., Morash, C., Armstrong, J., Meng, M., Lowe, P., Kogan, M.
Journal: Alternative Therapies in Health Medicine
Publication Date: May 29th, 2023
Citation: Altern Ther Health Med 29.4 (2023): 6-17.
Integrative Oncology Care of Symptoms of Anxiety and Depression in Adults with Cancer: Society for Integrative Oncology-ASCO Guideline
Authors: Carlson, L.E., Ismaila, N., Addington, E.L., et al
Journal: Journal of Clinical Oncology
Publication Date: August 15th, 2023
Citation: Journal of Clinical Oncology (2023): JCO-23
Mistletoe Extracts During the Oncological Perioperative Period: A Systematic Review and Meta-Analysis of Human Randomized Controlled Trials
Authors: Cogo, E., Elsayed, M., Sukriti, B. et al
Journal: Current Oncology
Publication Date: September 6th, 2023
Citation: Current Oncology 30.9 (2023): 8196-8219.
Dietary Supplements to Reduce Symptom Severity and Duration in People with SARS-CoV-2: A Double-Blind, Randomized Controlled Trial
Authors: Seely, D., Legacy, M., Conte, E. et al
Journal: BMJ Open
Publication Date: September 22nd, 2023
Citation: BMJ open 13.9 (2023): e073761
A Survey of Multidisciplinary Healthcare Providers Utilizing the KNOWintegrativeoncology.org Educational Platform
Authors: Green, J., Wright, H., Seely, D., Legacy, M., Anderson, M., Armstrong, H., Martell, C., Soles, S., Balneaves, LG.
Journal: BMC Complementary Medicine Therapies
Publication Date: 2022
Citation: BMC complementary medicine and therapies 22.1 (2022): 1-8
Exploring the Effects of Yoga Therapy on Heart Rate Variability and Patient-Reported Outcomes After Cancer Treatment: A Study Protocol
Authors: Brunet, J., Wurz, A., Hussein, J., Pitman, A., Conte, E., Ennis, J., Herry, C., Seely, AJE., Seely, D.
Journal: Integrative Cancer Therapies
Publication Date: 2022
Citation: Integrative cancer therapies 21 (2022): 15347354221075576.
Dietary Supplements to Reduce Symptom Severity and Duration in People with SARS-CoV-2: Study Protocol for a Randomized, Double Blind, Placebo Controlled Clinical Trial
Authors: Legacy, M., Seely, D., Conte, E., Psihogios, A., Ramsay, T., Fergusson, D., Kanji, S., Simmons, JG., Wilson, K.
Journal: BMJ Open
Publication Date: March 3, 2022
Citation: BMJ open 12.3 (2022): e057024
Naturopathy: Practice, Effectiveness, Economics and Safety. Chapter 29: Complex Naturopathic Interventions
Authors: Care, J., Smith, C., Burgos-Arias, A., Seely, D.
Organization: World Naturopathic Foundations
Publication Date: 2021
Editors: Lloyd, I., Steel, A., Wardle, J.
Read the full publication here
Naturopathy: Practice, Effectiveness, Economics and Safety. Chapter 17: Cancer and Cancer-Related Conditions
Authors: Schloss, J., Brown, D., Seely, D.
Organization: World Naturopathic Foundations
Publication Date: 2021
Editors: Lloyd, I., Steel, A., Wardle, J.
Read the full publication here
Are Supplemental Branched-Chain Amino Acids Beneficial During the Oncological Peri-Operative Period: A Systematic Review and Meta Analysis
Authors: Cogo, E., Elsayed, M., Liang, V., Cooley, K., Guerin, C., Psihogios, A., Papadogianis, P.
Journal: Integrative Cancer Therapies
Publication Date: 2021
Citation: Integrative cancer therapies 20 (2021): 1534735421997551
Adjuvant Melatonin for the Prevention of Recurrence and Mortality Following Lung Cancer Resection: A Randomized Placebo Controlled Clinical Trial
Authors: Seely, D., Legacy, M., Auer, R., et al
Journal: E-Clinical Medicine
Publication Date: March 2021
Citation: EClinicalMedicine 33 (2021): 100763.
Elderberry for Prevention and Treatment of Viral Respiratory Illnesses: A Systematic Review
Authors: Wieland, S., Piechotta, V., Feinberg, T., Ludeman, E., Hutton, B., Kanji, S., Seely, D., Garritty, C.
Journal: BMC Complementary Medicine Therapies
Publication Date: April 7, 2021
Citation: BMC complementary medicine and therapies 21.1 (2021): 1-15
Metformin and Cancer: Is There Value for the Non-Diabetic Patient?
Authors: Flower, G.
Journal: Canadian Journal of Naturopathic Medicine
Publication Date: June 9, 2021
Hyperthermia in Cancer Care: A Literature Review
Authors: Conte, E., Psihogios, Seely, D.
Journal: Journal of the Canadian Association of Naturopathic Doctors
Publication Date: September 30, 2021
Citation: CAND Journal 28.3 (2021): 14-30.
Probiotics Evaluation in Oncological Surgery: A Systematic Review of 36 Randomized Controlled Trials Assessing 21 Diverse Formulations
Authors: Cogo, E., Elsayed, M., Liang, V., Cooley, K., Guerin, C., Psihogios, A., Papadogianis, P.
Journal: Current Oncology
Publication Date: December 7, 2021
Citation: Current Oncology 28.6 (2021): 5192-5214
A Prospective Outcomes Pilot Evaluation of Inspire Now: A Program for People with Lung Cancer
Authors: Conte, E., Legacy, M., Psihogios, A., Pitman, A., Redway, A., Hamer-Wilson, J., Seely, D.
Journal: Integrative Cancer Therapies
Publication Date: 2020
Citation: Integrative cancer therapies 19 (2020): 1534735420983472
Does Integrative Medicine Reduce Prescribed Opioid Use for Chronic Pain? A Systematic Literature Review
Authors: Hassan, S., Zheng, Q., Rizzolo, E., Tezcanli, E., Bhardwaj, S., Cooley, K.
Journal: Pain Medicine
Publication Date: April 2020
Citation: Pain Medicine 21.4 (2020): 836-859
Integrative Oncology: International Perspectives
Authors: Grant, S.J., Hunter, J., Seely, D., Balneaves, L.G., Rossi, E., & Bao, T.
Journal: Integrative Cancer Therapies
Publication Date: 2019
Citation: Integrative cancer therapies 18 (2019): 1534735418823266
Chapter 5: Women's Cancers and Complementary and Integrative Medicine
Authors: Schloss, J., Alschuler, L., & McDonell, E.
Book: Women's Health and Complementary and Integrative Medicine
Publication Date: 2019
Milk thistle (Silybum marianum)
Authors: McDonell, E., Green, J., & Kalisch, A.
Location: CAM-Cancer Consortium
Publication Date: January 29, 2019
Intervention Development Process for a Pragmatic Randomized Controlled Trial: The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial
Authors: Seely, D., Ennis, J.E., McDonell, E., et al.
Journal: Journal of Alternative and Complementary Medicine
Publication Date: March 19, 2019
Citation: The Journal of Alternative and Complementary Medicine 25.S1 (2019): S112-S123
A systematic review of acupuncture for chemotherapy-induced peripheral neuropathy
Authors: Li, K., Giustini, D., & Seely, D.
Journal: Current Oncology
Publication Date: April 1, 2019
Citation: Current Oncology 26.2 (2019): 4261
Editorial: The Oncology Association of Naturopathic Physicians Principles of Care Guidelines
Authors: Seely, D., & Verma, S.
Journal: Current Oncology
Publication Date: February 1, 2019
Citation: Current Oncology 26.1 (2019): 8-9
Intravenous Vitamin C in the Supportive Care of Cancer Patients: A Review and Rational Approach
Authors: Klimant, E., Wright, H., D. Rubin, Seely, D. & Markman, M.
Publication: Current Oncology
Citedate: April 30, 2018
Citation: Current oncology 25.2 (2018): 139-148
An N-of-1 Feasibility Study of Homeopathic Treatment for Fatigue in Patients Receiving Chemotherapy
Authors: Brulé, D., Balon, .J., Zhao, L., & Seely, D.
Journal: Homeopathy
Publication Date: August 2018
Citation: Homeopathy 107.03 (2018): 196-201
North American Naturopathic Medicine in the 21st Century: Time for a Seventh Guiding Principle - Scientia Critica
Authors: Logan, A., Goldenberg, J., Guiltinan, J., Seely, D., Katz, D.
Journal: Explore (NY)
Publication Date: September 2018
Citation: Explore 14.5 (2018): 367-372
Boswellia spp
Authors: McDonell, E., Dennert, G., & CAM-Cancer Consortium.
Location: CAM-Cancer Consortium.
Publication Date: September 11, 2018
Naturopathic Oncology Care for Thoracic Cancers: A Practice Survey
Authors: Seely, D., Ennis J.K., McDonell, E., & Zhao. L.
Journal: Integrative Cancer Therapies
Publication Date: September 2018
Citation: Integrative cancer therapies 17.3 (2018): 793-805
Fish-Derived Omega-3 Fatty Acids and Prostate Cancer: A Systematic Review
Authors: Aucoin, M. , Cooley, K., Knee, C., Fritz, H., Balneaves, L.G., Breau, R., Fergusson, D., Skidmore, B., Wong, R., & Seely, D.
Journal: Integrative Cancer Therapies
Publication Date: March 2017
Citation: Integrative cancer therapies 16.1 (2017): 32-62.
Clinical Practice Guidelines on the Evidence-Based use of Integrative Therapies During and After Breast Cancer Treatment
Authors: Greenlee, H., DuPont-Reyes, M.J., Balneaves, L.G., Carlson, L., Cohen, M.R., Deng, G., Johnson, J.A., Mumber, M., Seely, D., Zick, S.M., Boyce, L.M., & Tripathy, D.
Journal: A Cancer Journal for Clinicians
Publication Date: May 6, 2017
Citation: CA: a cancer journal for clinicians 67.3 (2017): 194-232
Personal Goals of Women Recently Diagnosed with Breast Cancer: Protocol For a Cohort Study
Authors: Chow, A.J., Fergusson, D.A., Seely, D., Young, S., Pitman, A., Ennis, J., Asad, S., Presseau, J.
Journal: University of Ottawa Journal of Medicine
Publication Date: November 2017
Citation: University of Ottawa Journal of Medicine 7.2 (2017): 34-41
Naturopathic Oncology Modified Delphi Panel
Authors: Hill, J., Hodsdon, W., Schor, J., McKinney, N., Rubin, D., Seely, D., Parmar, G., Birdsall, T., Alschuler, L., Lamson, D., Birdsall, S., & Zwickey, H.
Journal: Integrative Cancer Therapies
Publication Date: March 2016
Citation: Integrative Cancer Therapies 15.1 (2016): 69-79
Qualitative assessment of information and decision support needs for managing menopausal symptoms after breast cancer
Authors: Balneaves, L.G., Panagiotoglou, D., Brazier, A.S., Lambert, L.K., Porcino, A., Forbes, M., Van Patten, C., Truant, T.L., Seely, D., & Stacey, D.
Journal: Supportive Care in Cancer
Publication Date: June 8, 2016
Citation: Supportive Care in Cancer 24.11 (2016): 4567-4575
Estimated Effects of Whole-System Naturopathic Medicine in Select Chronic Disease Conditions: A Systematic Review
Authors: Oberg, E., Bradley, R., Cooley, K., Fritz, H., Goldenberg, JZ., Seely, D., Saxton, JD.
Journal: Alternative and Integrative Medicine
Publication Date: 2015
Citation: Altern Integ Med 4.192 (2015): 2
The Responsiveness, Content Validity, and Convergent Validity of the Measure Yourself Concerns and Wellbeing (MYCaW) Patient-Reported Outcome Measure
Authors: Jolliffe, R., Seers, H., Jackson, S., Caro, E., Weeks, L., & Polley, M.J.
Journal: Integrative Cancer Therapies
Publication Date: January 2015
Citation: Integrative Cancer Therapies 14.1 (2015): 26-34.
Polysaccharide K and Coriolus versicolor Extracts for Lung Cancer: A Systematic Review
Authors: Fritz, H., Kennedy, D.A., Ishii, M., Fergusson, D., Fernandes, R., Cooley, K., & Seely, D.
Journal: Integrative Cancer Therapies
Publication Date: May 2015
Citation: Integrative Cancer Therapies 14.3 (2015): 201-211.
Xenoestogens and breast cancer: chemical risk, exposure, and corporate power
Authors: Young, S., & Seely, D.
Book: Our Chemical Selves: Gender, Toxics, and Environmental Health. (Edited by Dayna Nadine Scott. UBC Press.)
Publication Date: 2015
ISBN: 978-0-7748-2834-5
Black Cohosh and Breast Cancer: A Systematic Review
Authors: Frtiz, H., Seely, D., McGowan, J., Skidmore, B., Fernandes, R., Kennedy, D.A., Cooley, K., Wong, R., Sagar, S., Balneaves, L.G., & Fergusson, D.
Journal: Integrative Cancer Therapies
Publication Date: January 2014
Citation: Integrative cancer therapies 13.1 (2014): 12-29
A Naturopathic Approach to the Prevention of Cardiovascular Disease: Cost-Effectiveness Analysis of a Pragmatic Multi-Worksite Randomized Clinical Trial
Authors: Herman, P., Szczurko, O., Cooley, K., Seely, D.
Journal: Journal of Occupational and Environmental Medicine
Publication Date: February 2014
Citation: Journal of occupational and environmental medicine 56.2 (2014): 171
Developing an Operational Model for an Integrative Oncology Program: A Qualitative Descriptive Feasibility Study
Authors: Weeks, L., Seely, D., DeGrasse, C., Verma, S., Boon, H., Verhoef, M., & Stacey, D.
Journal: Supportive Care In Cancer
Publication Date: March 2014
Citation: Supportive Care in Cancer 22.3 (2014): 731-739
Decision-Making About Complementary and Alternative Medicine by Cancer Patients: Integrative Literature Review
Authors: Weeks, L., Balneaves, L.G., Paterson, C., Verhoef, M.
Journal: Open Medicine
Publication Date: April 15, 2014
Citation: Open Medicine 8.2 (2014): e54
Flax and Breast Cancer: A Systematic Review
Authors: Flower, G., Frtiz, H., Balneaves, L.G., Verma S, Skidmore, B., Fernandes, R., Kennedy, D.A., Cooley, K., Wong, R., Sagar, S., Fergusson, D., & Seely, D.
Journal: Integrative Cancer Therapies
Publication Date: May 2014
Citation: Integrative cancer therapies 13.3 (2014): 181-192
Intravenous Vitamin C and Cancer: A Systematic Review
Authors: Fritz, H., Flower, G., Weeks, L., Cooley, K., Callachan, M., McGowan, J., Skidmore, B., Kirchner, L., & Seely, D.
Journal: Integrative Cancer Therapies
Publication Date: July 2014
Citation: Integrative cancer therapies 13.4 (2014): 280-300
Clinical Practice Guidelines on the Use of Integrative Cancer Therapies as Supportive Care in Patients Treated for Breast Cancer
Authors: Greenlee, H., Balneaves, L.G., Carlson, L.E., Cohen, M., Deng, G., Hershman, D., Mumber, M., Perlmutter, J., Seely, D., Sen, A., Zick, S.M., Tripathy, D. & Society for Integrative Oncology Guidelines Working Group
Journal: The Journal of the National Cancer Institute Monographs
Publication Date: November 2014
Citation: JNCI Monographs 2014.50 (2014): 346-358
Assessing the Utility of an Electronic Research Database to Capture Whole Systems Practice at Two Naturopathic Outpatient Teaching Clinics
Authors: Leung, B., Flower, G., Cooley, K., Habib, C., Gowan, M., Podgrabinsky, S., Seely, D.
Journal: Journal of Evidence-Based Complementary and Alternative Medicine
Publication Date: 2013
Citation: Journal of Evidence-Based Complementary & Alternative Medicine 18.3 (2013): 170-175
Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review
Authors: Kennedy, D.A., Cooley, K., Skidmore, B., Fritz, H., Campbell, T., Seely, D.
Journal: Cancers
Publication Date: March 11, 2013
Citation: Cancers 5.1 (2013): 255-280
Naturopathic Medicine for the Prevention of Cardiovascular Disease: A Randomized Clinical Trial
Authors: Seely, D., Szczurko, O., Cooley, K., et al
Journal: Canadian Medical Association Journal
Publication Date: June 11, 2013
Citation: CMAJ 185.9 (2013): E409-E416
Canadian Integrative Oncology Research Priorities: Results of a Consensus-Building Process
Authors: Weeks, L.C., Seely, D., Balneaves, L.G., Boon, H.S., Leis, A., Oneschuk, D., Sagar, S.M., & Verhoef M.J.
Journal: Current Oncology
Publication Date: August 2013
Citation: Current Oncology 20.4 (2013): 289-299
Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review
Authors: Frtiz, H., Seely, D., Flower, G., Skidmore, B., Fernandes, R., Vadeboncoeur, S., Kennedy, D.A., Cooley, K., Wong, R., Sagar, S., Sabri E, & Fergusson, D.
Journal: PLOS One
Publication Date: November 28, 2013
Citation: PloS one 8.11 (2013): e81968
Green tea and lung cancer: a systematic review
Authors: Fritz, H., Seely, D., Kennedy, D.A., Fernandes, R., Cooley K., & Fergusson, D.
Journal: Integrative Cancer Therapies
Publication Date: April 24, 2012
Citation: Integrative Cancer Therapies 12.1 (2013): 7-24
Objective Assessment of an Ionic Footbath (IonCleanse): Testing its Ability to Remove Potentially Toxic Elements from the Body
Authors: Kennedy, D.A., Cooley, K., Einarson, T.R., Seely, D.
Journal: Journal of Environmental and Public Health
Publication Date: 2012
Citation: Journal of Environmental and Public Health 2012 (2012)
Treating Type 2 Diabetes: A Cross-Sectional Audit of Naturopathic Standards of Care Using the Naturopathic Patient Database
Authors: Habib, C., Gowan, M., Podgrabinsky, S., Grodski, T., Leung, B., Shapoval, M., Seely, D., Cooley, K.
Journal: Journal of Evidence Based Complementary and Alternative Medicine
Publication Date: March 22, 2012
Citation: JEBCAM. 2012;17(2):108-116
Interactions of Commonly Used Dietary Supplements with Cardiovascular Drugs: A Systematic Review
Authors: Kanji, S., Seely, D., Yazdi, F., et al
Journal: Systematic Reviews
Publication Date: May 31, 2012
Citation: Systematic reviews 1.1 (2012): 1-16
A systematic review of integrative oncology programs
Authors: Seely, D., Weeks, L.C., & Young S.
Journal: Current Oncology
Publication Date: December 2012
Citation: Current oncology 19.6 (2012): 436-461
Melatonin as Adjuvant Cancer Care With and Without Chemotherapy: A Systematic Review and Meta-analysis of Randomized Trials
Authors: Seely, D., Wu P., Frtiz, H., Kennedy, D.A., Tsui, T., Seely A., & Mills, E.
Journal: Integrative Cancer Therapies
Publication Date: December 2012
Citation: Integrative cancer therapies 11.4 (2012): 293-303
Randomized, Double Blind, Placebo Controlled Pilot Study Assessing the Ability of Inositol Hexaniacinate (Hexanicotinate) to Reduce Symptoms of Non-Ulcer Dyspepsia Possibly Due to Insufficient Hydrochloric Acid Production
Authors: Prousky, J.E., Seely, D.
Journal: Journal of Orthomolecular Medicine
Publication Date: 2011
Citation: Journal of Orthomolecular Medicine. 26.1 (2011): 21-31
Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis
Authors: Fritz, H. Kennedy, D., Fergusson, D., Fernandes, R., Doucette, S., Cooley, K., Seely, A., Sagar, S., Wong, R., & Seely D.
Journal: PLOS One
Publication Date: June 27, 2011
Citation: PloS one 6.6 (2011): e21107
Describing Reporting Guidelines for Health Research: A Systematic Review
Authors: Moher, D., Weeks, L., Ocampo, M. et al
Journal: Journal of Clinical Epidemiology
Publication Date: July 2011
Citation: Journal of clinical epidemiology 64.7 (2011): 718-742
Effect of Selenium Supplementation on CD4 T-Cell Recovery, Viral Suppression, Morbidity and Quality of Life of HIV-Infected Patients in Rwanda: Study Protocol for a Randomized Controlled Trial
Authors: Kamwesiga, J., Mutabazi, V., Kayumba, J. et al
Journal: Trials
Publication Date: August 13, 2011
Citation: Trials 12.1 (2011): 1-7
Selenium and lung cancer: a systematic review and meta analysis
Authors: Frtiz, H., Kennedy D, Fergusson, D., Fernandes, R., Cooley, K., Seely A, Sagar, S., Wong, R., & Seely, D.
Journal: PLOS One
Publication Date: November 4, 2011
Citation: PLOS One 6.11 (2011): e26259
Shifting the paradigm: from complementary and alternative medicine (CAM) to integrative oncology
Authors: Leis, A., Sagar, S., Verhoef, M., Balneaves, L., Seely, D., & Oneschuk D.
Book: Cancer Control. (Eedited by Elwood JM and Sutcliffe SB. Oxford University Press, Oxford, UK.)
Publication Date: 2010
ISBN: 978-0-19-955017-3
Clinically Based Evidence of Drug-Herb Interactions: A Systematic Review
Authors: Kennedy, D.A., Seely, D.
Journal: Expert Opinion on Drug Safety
Date Published: January 2010
Citation: Expert opinion on drug safety 9.1 (2010): 79-124
Acupuncture in Post-Stroke Rehabilitation: A Systematic Review and Meta-Analysis of Randomized Trials
Authors: Wu, P., Mills, E., Moher, D., Seely, D.
Journal: Stroke
Date Published: April 2010
Citation: Stroke 41.4 (2010): e171-e179
Astralagus-containing Chinese herbal combinations for advanced non-small-cell lung cancer: A meta-analysis of 65 clinical trials enrolling 4,751 patients
Authors: Dugoua, J.J., Wu, P., Seely, D., Eyawo, O., & Mills, E.
Journal: Lung Cancer: Targets and Therapy
Date Published: July 2010
Citation: Lung Cancer: Targets and Therapy 1 (2010): 85
Naturopathic Medicine and Aboriginal Health: An Exploratory Study at Anishnawbe Health Toronto
Authors: Walji, R., Weeks, L., Cooley, K., Seely, D.
Journal: Canadian Journal of Public Health
Publication Date: November 2010
Citation: Canadian Journal of Public Health 101.6 (2010): 475-480
A Case Report on the Successful Use of Inositol Hexaniacinate for the Treatment of Achlorhydria: Its Possible Mechanism of Action Upon the Central Nervous System and Parietal Cell-Adenosine Triphosphate-Dependent K+/H+ Pump
Authors: Prousky, J., Seely, D.
Publisher: Townsend Letter
Publication Date: February 2003
The Treatment of Migraines and Tension-Type Headaches with Intravenous and Oral Niacin (Nicotinic Acid): Systematic Review of the Literature
Authors: Prousky, J., Seely, D.
Journal: Nutrition Journal
Publication Date: Jan 26, 2005
Citation: Nutrition Journal 4.1 (2005): 1-7
African Herbal Medicines in the Treatment of HIV: Hypoxis and Sutherlandia. An Overview of Evidence and Pharmacology
Authors: Mills, E., Cooper, C., Seely, D., Kanfer, I.
Journal: Nutrition Journal
Publication Date: May 2005
Citation: Nutrition journal 4.1 (2005): 1-6
Vitamin Supplementation for Prevention of Mother-to-Child Transmission of HIV and Pre-Term Delivery: A Systematic Review of Randomized Trials Including more than 2800 Women
Authors: Mills, E.J., Wu, P., Seely, D., Guyatt, G.H.
Journal: AIDS Research and Therapy
Publication Date: May 6, 2005
Citation: AIDS Research and Therapy 2.1 (2005): 1-7
The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review
Author: Seely, D., Mills, E.J., Wu, P., Verma, S., & Guyatt, G.H.
Journal: Integrative Cancer Therapies
Publication Date: June 2005
Citation: Integr Cancer Ther. 2005;4(2):144-55.
EDTA Chelation Therapy for Cardiovascular Disease: A Systematic Review
Authors: Seely, D., Wu, P., Mills, E.J.
Journal: BMC Cardiovascular Disorders
Publication Date: November 2005
Citation: BMC Cardiovascular Disorders 5.1 (2005): 1-6
Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis
Authors: Mills. E., Wu, P., Seely, D., & Guyatt, G.
Journal: Journal of Pineal Research
Publication Date: November 2005
Citation: Journal of pineal research 39.4 (2005): 360-366
Safety and Efficacy of Black Cohosh (Cimicifuga Racemosa) During Pregnancy and Lactation
Authors: Dugoua, J., Seely, D., Perri, D., Koren, G., Mills, E.
Journal: Journal of Therapeutics and Clinical Pharmacology
Publication Date: 2006
Citation: Journal of Population Therapeutics and Clinical Pharmacology 13.3 (2006)
Textbook of Complementary and Alternative Medicine. Chapter 21: Naturopathic Medicine
Authors: Seely, D.
Editors: Yuan, C., Bieber, E.
Publisher: Parthenon Publishing
Publication Date: 2006
ISBN: 1-84214-297-6
Read a preview of the book here
Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors
Authors: Mills, E.J., Seely, D., Rachlis, B., Griffith, L., Wu, P., Wilson, K., Ellis, P., & Wright, J.R.
Journal: Lancet Oncology
Publication Date: February 2006
Citation: Lancet Oncology, 2006;7(2):141-8.
Metronomic dosing of chemotherapy: applications in pediatric oncology
Authors: Stempak, D., Seely, D., & Baruchel, S.
Journal: Cancer Investigation
Publication Date: June 2006
Citation: Cancer Invest. 2006;24(4):432-43.
An In Vivo Analysis of the Herbal Compound Essiac
Authors: Leonard, B.J., Kennedy, D.A., Cheng, F.C., Chang, K.K., Seely, D., Mills, E.
Journal: Anticancer Research
Publication Date: July 2006
Citation: Anticancer research 26.4B (2006): 3057-3063
Diagnostic Accuracy Among the Allied Health Professions: Commentary on Grace et al
Authors: Seely, D., Mills, E.
Journal: Journal of Alternative and Complementary Medicine
Publication Date: September 13, 2006
Citation: Journal of Alternative & Complementary Medicine 12.7 (2006): 701-702
A strategy for controlling potential interactions between natural health products and chemotherapy: a review in pediatric oncology
Authors: Seely, D., Stempak, D., & Baruchel, S.
Journal: Journal of Pediatric Hematology/Oncology
Publication Date: January 2007
Citation: Journal Pediatric Hematol Oncol, 2007;29(1):32-47.
Adaptogenic Potential of a Polyherbal Natural Health Product: Report on a Longitudinal Clinical Trial
Authors: Seely, D., Singh, R.
Journal: Journal of Evidence Based Complementary and Alternative Medicine
Publication Date: September 2007
Citation: Evidence-Based Complementary and Alternative Medicine 4.3 (2007): 375-380
From Type 2 Diabetes to Antioxidant Activity: A Systematic Review of the Safety and Efficacy of Common Cassia and Cinnamon Bark
Authors: Dugoua, J., Seely, D., Perri, D., Cooley, K., Forelli, T., Mills, E., Koren, G.
Journal: Canadian Journal of Physiology and Pharmacology
Publication Date: September 2007
Citation: Canadian journal of physiology and pharmacology 85.9 (2007): 837-847
Encyclopedia of Cancer and Society. Flame Retardants and Cancer Risk
Authors: Seely, D., Fernandes, R., Young, S.
Editor: Graham A. Colditz
Publisher: SAGE Publications
Publication Date: September 12, 2007
ISBN: 978-1-4129-4989-7
Read a preview of the book here
Naturopathic Care for Chronic Low Back Pain: A Randomized Trial
Authors: Szczurko, O., Cooley, K., Busse, J.W., Seely, D., Bernhardt, B., Guyatt, G.H., Zhou, Q., Mills, E.J.
Journal: PLOS One
Publication Date: September 19, 2007
Citation: PLoS One 2.9 (2007): e919
In vitro analysis of the herbal compound Essiac
Authors: Seely, D., Kennedy, D.A., Myers, S.P., Cheras, P.A., Lin, D., Li, R., Cattley, T., Brent, P.A., Mills, E., Leonard, B.J.
Journal: Anticancer Research
Publication Date: November 2007
Citation: Anticancer Research, 2007;27(6B):3875-82.
Safety and Efficacy of Blue Cohosh (Caulophyllum Thalictroides) During Pregnancy and Lactation
Authors: Dugoua, J., Perri, D., Seely, D., Mills, E., Koren, G.
Journal: Journal of Population Therapeutics and Clinical Pharmacology
Publication Date: 2008
Citation: Journal of Population Therapeutics and Clinical Pharmacology 15.1 (2008): 66-73
Safety and Efficacy of Chastetree (Vitex Agnus-Castus) During Pregnancy and Lactation
Authors: Dugoua, J., Seely, D., Perri, D., Koren, G., Mills, E.
Journal: Journal of Population Therapeutics and Clinical Pharmacology
Publication Date: 2008
Citation: Journal of Population Therapeutics and Clinical Pharmacology 15.1 (2008): 74-79
Safety and Efficacy of Cranberry (Vaccinium Macrocarpon) During Pregnancy and Lactation
Authors: Dugoua, J., Seely, D., Perri, D., Mills, E., Koren, G.
Journal: Journal of Population Therapeutics and Clinical Pharmacology
Publication Date: 2008
Citation: Journal of Population Therapeutics and Clinical Pharmacology 15.1 (2008): 80-86
Safety and Efficacy of Panax Ginseng During Pregnancy and Lactation
Authors: Seely, D., Dugoua, J., Perri, D., Mills, E., Koren, G.
Journal: Journal of Population Therapeutics and Clinical Pharmacology
Publication Date: 2008
Citation: Journal of Population Therapeutics and Clinical Pharmacology 15.1 (2008): 87-94
Naturopathic Medicine for Improved Healthcare Within Canadian Aboriginal Communities
Authors: Seely, D., Kennedy, D., Walji, R., McCarthy, J., Cooley, K., Grobys, S., Weeks, L.
Publisher: Canadian Health Workforce Network
Publication Date: July 2008
Patient decision-making about complementary and alternative medicine in cancer
Authors: Balneaves, L.G., Weeks, L., & Seely, D.
Journal: Current Oncology
Publication Date: August 2008
Citation: Current Oncology, 2008;15 Suppl 2:s94-s100.
Interactions of natural health products with biomedical cancer treatments
Authors: Seely, D., Oneschuk, D.
Journal: Current Oncology
Publication Date: August 2008
Citation: Current Oncology, 2008; 15 Suppl 2:s109.es81-10.es86.
Integrative practices of Canadian oncology health professionals
Auhours: Brazier, A.S., Balneaves, L.G., Seely, D., Stephen, J.E., Suryaprakash, N., Taylor-Brown, J.W.
Journal: Current Oncology
Publication Date: August 2008
Citation: Current Oncology, 2008 Aug;15 Suppl 2:s110.es87-91.
Links Between ADHD and Environmental Pollutants: Implications for Preventative Naturopathic Clinical Practice
Authors: Seely, D., Cooley, K., Fritz, H.
Publisher: The Townsend Letter
Publication Date: February 2009
A comparative review of thermography as a breast cancer screening technique
Authors: Kennedy, D., Lee, T., & Seely, D.
Journal: March 2009
Publication Date:
Citation: Integrative Cancer Therapies 2009;8(1):9-16.
Guidelines to Case Report Writing for Naturopathic Doctors
Authors: Leung, B., Seely, D.
Journal: International Journal of Naturopathic Medicine
Publication Date: July 2009
Citation: Int J Naturopathic Med 4.1 (2009): 50-54
Naturopathic Treatment of Rotator Cuff Tendinitis Among Canadian Postal Workers: A Randomized Controlled Trial
Authors: Szczurko, O., Cooley, K., Mills, E.J., Zhou, Q., Perri, D., Seely, D.
Journal: Arthritis Care and Research
Publication Date: August 15, 2009
Citation: Arthritis Care & Research 61.8 (2009): 1037-1045
Naturopathic Care for Anxiety: A Randomized Controlled Trial
Authors: Cooley, K., Szczurko, O., Perri, D., Mills, E.J., Berndhart, B., Zhou, Q., Seely, D.
Journal: PLOS One
Publication Date: August 31, 2009
Citation: PLoS One 4.8 (2009): e6628
Cost Effectiveness of Natural Health Product: A Systematic Review of Randomized Clinical Trials
Authors: Kennedy, D., Hart, J., Seely, D.
Journal: Evidence Based Complementary and Alternative Medicine
Publication Date: September 2009
Citation: Evidence-Based Complementary and Alternative Medicine 6.3 (2009): 297-304
Research Funders
The CHI gratefully acknowledges support of our research funders.
The primary goal of the Canadian Complementary and Alternative Medicine Research Fund (CCRF) is to increase and enhance complementary medicine research capacity in Canada by supporting and funding relevant and high caliber studies. Funding through the CCRF has being used to support two studies: 1) Towards Integrative Cancer Care: A Participatory, Formative Evaluation of Practitioner Integration at the Ottawa Integrative Cancer Centre; and 2) An n-of-1 study of homeopathic treatment of fatigue in patients receiving chemotherapy.
The Canadian Institutes of Health Research (CIHR) is the Government of Canada’s premier agency for health research. Funding through the CIHR has being used to support OICC efforts towards: Developing a Community-Based Integrative Oncology Research Program. CIHR funding has also helped support two large scale synthesis reviews on natural health products used by people with lung and breast cancer respectively and led to a number of open access publications.
Since their beginning nearly 20 years ago, the Gateway for Cancer Research has sought better treatment options for cancer patients—options that extend life, improve quality of life, and strive to cure people.
One of the Lotte and John Hecht Memorial Foundation's two major objectives is to support the investigation and support of complementary and alternative medicine, particularly in the treatment of cancer. Funding through the Lotte and John Hecht Memorial Foundation initially supported a multi-phase feasibility study that informed the development of the OICC model. In addition, the Hecht foundation is the main supporter of the multi-site Canadian trial, the Adjuvant Melatonin in the Prevention of Recurrence and Mortality Following Lung Cancer Resection: A Randomized Placebo Controlled Clinical Trial (AMPLCaRe). Their support is also behind two of the major research projects that the OICC is running including CUSIOS and TPOISE.
INCAM is a collaborative and interdisciplinary research community in Canada generating knowledge through research on complementary, alternative, and integrative medicine/health care* to enhance the health of Canadians.
Since its launch in 2004, INCAM has been instrumental in defining a CAM research community in Canada. Today, INCAM is the place to go for researchers, educators and practitioners who are interested in research which aims to address challenging questions in innovative ways in this emerging area of practice and research.
[…] research at The Patterson Institute and other projects. Special thanks to our research coordinator, Mark Legacy, and research assistant, Dr. Erica Rizzolo, ND, for putting these posters together and presenting […]